Anti-GM1 Antibodies: anti-GM1 antibodies (IgG) are implicated in the pathogenesis of Guillain-Barré Syndrome (GBS) and anti-GM1 antibodies (IgM) in multifocal neuropathy (MMN) and lower motor neuron disease (LMND).

Anti-GM1 autoantibodies (IgM) may be present as monoclonal IgM paraprotein or as a polyclonal IgM. Polyclonal IgG may be detected in patients with motor neuropathies. High GM1 antibody titers may be detected in association with in Guillain-Barré Syndrome (GBS) following Campylobacter jejuni infection.

GM1 is the most relevant target antigen in neural tissue. The fact that GM1 is the only common glycolipid antigen reactive with all of the GM1 antibodies found in motor nerve disorders underlines its importance in immune-mediated peripheral neuropathies.

 

Method	ELISA
Time to Result	4.5 h (approx.)
Sample Type	20 µl serum (1:50)
Standard Range	quantitative
Isotypes	IgG and IgM
Order Code	EK-GM1-GM
	CE

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