Calprotectin is the best marker for IBD. It is an established measure to discriminate IBD from IBS and a very valuable tool to monitor the disease course of IBD patients (Crohn’s and ulcerative colitis). The technology platforms offered by BÜHLMANN range from the gold standard ELISA assay, BUHLMANN fCAL®, to the POC test, Quantum Blue®, to the new IBDoc® home test and to the automated random access BÜHLMANN fCAL® turbo assay. With this portfolio all possible applications for measuring calprotectin are covered from the patient’s home test to the high throughput lab.

Therapeutic Drug Monitoring

Over the past two decades great improvements in therapy of chronic inflammatory diseases have been made. The rise of TNFα biologics like adalimumab and infliximab has been a great step forward to ameliorating disease course and keep inflammations at remission levels for prolonged periods of time. Patients with suboptimal drug concentrations have worse outcomes than those with adequate drug levels.  Therapeutic drug monitoring (TDM) for adalimumab and infliximab has a great potential for the management of anti TNF therapy.


The Quantum Blue CRP test allows for a rapid determination of serum CRP within 22 minutes. It is an ideal tool to accompany the calprotectin determination for establishing an IBD patient inflammation profile during the course of the disease. The combination of the two markers has shown to increase the specificity for detecting inflammation in Crohn’s disease. The ease of use and speed of these two tests on the Quantum Blue® platform make this technology a very convenient addition to the therapy monitoring chronic inflammation of the gut.

Quantum Blue

The Quantum Blue® Calprotectin rapid test is a sensitive, non-invasive tool to pre-select patients requiring colonoscopy for confirmation of organic bowel disease (IBD). Quantitative results for calprotectin concentration (in ug/g stool) are available within 12 minutes and are very comparable to the established BÜHLMANN fCAL® ELISA.


IBDoc® is the first in-vitro diagnostic home testing device measuring the inflammatory marker fecal calprotectin at home. The CalApp® turns your smartphone into a test cassette reader using state of the art image processing. Stool extraction is performed using the Calex® Valve that is characterized by its simple and convenient handling of stool samples.  The secure connection of CalApp® with IBDoc® Portal allows Health Care Professionals to directly monitor patient results.


Immunoturbidimetry allows fast, flexible and random access applications with high precision. BÜHLMANN offers immunoturbidimetric solutions for the two gastroenterological markers fecal Calprotectin and pancreatic Elastase. The combination of both tests with the CALEX® Cap extraction device provides the best possible degree of automation for quantitative stool analysis.

Extraction / CALEX

Calex® Cap extraction device offers an efficient, convenient and hygienic extraction of stool samples. Its simple design makes it an ideal extraction device characterized not only by high safety but also by offering high stability of stool samples.