BÜHLMANN is proud to release the first Polyethylene glycol (PEG) Allergens for the Flow CAST® basophil activation assay. During the last weeks, we received many requests from experts in the field who asked for PEG allergens, The Flow CAST® is a powerful laboratory test to investigate the patients’ hypersensitivity reactions to PEG. These reactions are suspected to be responsible for the rarely observed adverse reactions to the COVID-19 vaccines.
Allergic and adverse reactions to vaccines are rare and the occurrence of such events should not deter patients from getting a vaccination. Maintenance of vaccine safety requires a proactive approach to maintain public confidence1.
Vigilance and clinical management of patients during vaccinations are essential, but this approach should also include the understanding of any allergic or adverse reactions’ mechanisms of action, identification of the culprit substance in the vaccines’ formulation, and a proposed warning for people at risk, before getting the vaccine.
Polyethylene glycols (PEG) are ingredients in the lipid formulation in some of the COVID-19 vaccines and are suspected to be the cause in adverse reactions1,2. First international recommendations clearly advice that patients with hypersensitivity reactions to PEG and Polysorbate should not be vaccinated.
Flow CAST® basophil activation testing is a powerful laboratory testing opportunity to investigate a potential patient’s hypersensitivity reaction to PEG3,4.